Which findings on epiluminescent surface microscopic exam suggest seborrheic keratosis?

Updated: Oct 14, 2020
  • Author: Arthur K Balin, MD, PhD, FACP; Chief Editor: William D James, MD  more...
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Epiluminescent surface microscopic examination of seborrheic keratoses reveals globulelike structures. The globule like structures in seborrheic keratoses are due to intraepidermal horn cysts filled with cornified cells containing melanin. They resemble the brown globules observed in melanocytic neoplasms, which are due to nests of melanocytes at the dermoepidermal junction.

Irritation can cause swelling and sometimes bleeding, oozing, and crusting and a deepening of the color due to inflammation.

Seborrheic keratoses may become red-brown in color when they become inflamed.

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