What causes seborrheic keratosis?

Updated: Oct 14, 2020
  • Author: Arthur K Balin, MD, PhD, FACP; Chief Editor: William D James, MD  more...
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Answer

Seborrheic keratoses are thought to result from a clonal expansion of a mutated epidermal keratinocyte. [1] (see Pathophysiology). Some cases are inherited through an autosomal dominant mode of inheritance. Sunlight seems to play a role in the development of some seborrheic keratoses. [17] Evidence indicates that at least some seborrheic keratoses have a clonal nature. Activating mutations in the gene encoding the tyrosine kinase receptor FGFR3 have been found in 85% of adenoid seborrheic keratoses. This is discussed in Pathophysiology section.


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