What is the role of oral isotretinoin in the management of sebaceous hyperplasia?

Updated: Oct 05, 2020
  • Author: David T Robles, MD, PhD, FAAD; Chief Editor: William D James, MD  more...
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Oral isotretinoin has proven effective in clearing some lesions after 2-6 weeks of treatment, but lesions often recur upon discontinuation of therapy. However, several cases of sustained improvement or clearance after cessation of therapy were reported in 2016, following cumulative doses ranging from 40-60 mg/kg. [38] Daily treatment doses range from 0.5 mg/kg/day to 1 mg/kg/day. [38] Maintenance doses of oral isotretinoin ranging from 10-40 mg every other day or 0.05% isotretinoin gel (not marketed in the United States) is rarely indicated as a suppressive treatment for widespread disfiguring sebaceous hyperplasia, which recurs despite therapy. [17, 39] Oral isotretinoin should be prescribed by a physician who is experienced in oral retinoid therapy and only for patients without contraindications and fully compliant with all restrictions on this medication. Other topical retinoids are considered less effective in treating this condition.

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