What is the prognosis of sebaceous hyperplasia?

Updated: Oct 05, 2020
  • Author: David T Robles, MD, PhD, FAAD; Chief Editor: William D James, MD  more...
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Sebaceous hyperplasia has no direct association with malignant degeneration and is not a cause of morbidity beyond cosmetic concerns. Sebaceous hyperplasia has been reported in association with internal malignancy in the setting of Muir-Torre syndrome. Muir-Torre syndrome is a rare autosomal dominant disorder in which visceral malignancies, sebaceous neoplasms (eg, sebaceous adenoma, sebaceous carcinoma), and keratoacanthoma coincide. Colon cancer is the leading internal malignancy associated with Muir-Torre syndrome, followed by hematologic malignancies. [26] Sebaceous hyperplasia alone does not signify a predisposition to cancer or represent a sign of Muir-Torre syndrome.

One study reported that 29.9% of patients with a renal transplant had sebaceous hyperplasia, and that 45.7% of these patients had a history of nonmelanoma skin cancer (NMSC), compared with 7.3% of patients without sebaceous hyperplasia. In this population, the association of NMSC with sebaceous hyperplasia remained significant after correction of factors such as age, sex, skin type, and duration since transplantation. [14] Thus, the presence of sebaceous hyperplasias in the setting of renal transplantation may serve as a marker for an elevated risk of NMSC.

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