What are other trigger factors of porokeratosis?

Updated: Oct 09, 2020
  • Author: Amarateedha Prak LeCourt, MD; Chief Editor: William D James, MD  more...
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Natural or artificial ultraviolet radiation, electron beam therapy, and extensive radiation therapy are well-established trigger factors for DSAP and PM. Sun exposure in genetically susceptible individuals is thought to cause DSAP, although the sparing of facial skin in most patients is unexplained.

Immunosuppression associated with porokeratosis may be secondary to a disease process or medications. Diseases reported in association with porokeratosis include HIV infection, [25] diabetes mellitus, [26] liver disease, [27] and hematologic or solid organ malignancy. [28, 29] Immunomodulating drugs used to treat autoimmune diseases or to prevent organ transplant rejection may also trigger porokeratosis. [30, 31, 32, 33, 34, 35, 36, 37, 38] Localized cutaneous immunosuppression due to long-term application of a potent topical steroid was reported to induce PM. [39] The incidence of porokeratosis in organ transplant recipients has been reported to be anywhere from 1-11%. [31, 34]

Immunosuppression may induce new lesions or cause preexisting lesions to flare. New lesions of porokeratosis have occurred as quickly as 4 months after initiation of immunosuppressive therapy, or as long as 14 years [34, 36] and may resolve following cessation of immunosuppressive therapy. [37, 38]

Trauma, such as a burn, may also trigger porokeratosis. [40]

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