What are "C" findings indicative of aggressive disease in patients with mastocytosis?

Updated: Jun 07, 2018
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: Dirk M Elston, MD  more...
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Answer

The additional presence of "C" findings, such as the following, is diagnostic for the presence of aggressive disease. [2]

  • Absolute neutrophil count less than 1000/µL (see the Absolute Neutrophil Count calculator)

  • Hemoglobin value less than 10 g/µL

  • Platelet count less than 100 000/µL

  • Hepatomegaly with ascites and impaired liver function

  • Palpable splenomegaly with hypersplenism

  • Malabsorption with hypoalbuminemia and weight loss

  • Large-sized osteolysis or severe osteoporosis causing pathologic fractures or life-threatening organopathy in other organ systems definitively caused by an infiltration of the tissue by neoplastic mast cells


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