What is the role of interferon-alfa in the treatment of mastocytosis?

Updated: Jun 07, 2018
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: Dirk M Elston, MD  more...
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Patients with aggressive systemic mastocytosis have disease-related organ dysfunction; interferon-alfa (with or without corticosteroids) can control dermatological, hematological, GI, skeletal, and mediator-release symptoms, but may be poorly tolerated. Cladribine has broad therapeutic activity, particularly when rapid debulking is indicated; the main toxicity is myelosuppression. Imatinib has a therapeutic role in the presence of an imatinib-sensitive KIT mutation or in patients with unmutated KITD816. [41]

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