What is the role of aspirin in the management of mastocytosis?

Updated: Jun 07, 2018
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: Dirk M Elston, MD  more...
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Answer

Cautious administration of aspirin to inhibit prostaglandin synthesis and maintain mast cell degranulation may be beneficial for patients with disease resistant to H1 and H2 antagonist therapy alone. The patient, premedicated with H1 and H2 antihistamines, may be started on small doses of aspirin, slowly titrated to reach a plasma level of 20-30 mg/100 mL. Initiate this treatment regimen in a controlled environment, because aspirin can induce mast cell mediator release and subsequent cardiovascular collapse.


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