Which medications in the drug class Antineoplastic Agents are used in the treatment of Keloid and Hypertrophic Scar?

Updated: Jun 12, 2018
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antineoplastic Agents

These agents inhibit cell growth and proliferation.

Bleomycin

Injections cause necrosis of keratinocytes. It is not approved by the FDA for use in hypertrophic scars and keloids.

Fluorouracil topical (Adrucil)

Fluorouracil is a pyrimidine analog that inhibits fibroblastic proliferation in tissue culture and is believed to reduce postoperative scarring by decreasing fibroblast proliferation. It is not approved by the FDA for use in hypertrophic scars and keloids.

Doxorubicin (Adriamycin)

Doxorubicin irreversibly inactivates prolyl 4-hydroxylase in human skin fibroblasts and inhibits collagen alpha-chain assembly.  It is not approved by the FDA for use in hypertrophic scars and keloids.

Tamoxifen

Tamoxifen competitively binds to estrogen receptors, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects.


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