Which medications in the drug class Retinoid-like Agents are used in the treatment of Keloid and Hypertrophic Scar?

Updated: May 29, 2020
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Retinoid-like Agents

These agents decrease normal tonofilament and keratohyalin synthesis, increase the production of mucoid substances and the epidermal cell growth rate, and inhibit DNA synthesis in vitro.

Tretinoin topical (Retin-A, Retin-A Micro, Renova)

Although the exact mechanism of action is unknown, retinoids decrease the cohesiveness of abnormal hyperproliferative keratinocytes, modulate keratinocyte differentiation, and have anti-inflammatory properties. It is not approved by the FDA for use in hypertrophic scars and keloids.

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