Which medications in the drug class Immunosuppressants are used in the treatment of Keloid and Hypertrophic Scar?

Updated: Jun 12, 2018
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Immunosuppressants

These agents inhibit immune processes that promote inflammation.

Tacrolimus ointment (Protopic)

Tacrolimus suppresses release of cytokines from T cells. It also inhibits transcription for genes that encode interleukin 3 (IL-3), IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor–alpha (TNF-alpha), all of which are involved in the early stages of T-cell activation.

Additionally, tacrolimus may inhibit release of preformed mediators from skin mast cells and basophils and may down-regulate expression of high-affinity IgE receptor (FCeRI) on Langerhans cells. It is not approved by the FDA for use in hypertrophic scars and keloids.


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