What is the role of Narrowband UVB in the treatment of keloids and hypertrophic scars?

Updated: Jun 12, 2018
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Narrowband UVB in the wavelength range of 310-315 nm (peak at 312 nm) has demonstrated for more than 20 years to be less potent than broadband UVB for erythema induction, hyperplasia, edema, sunburn cell formation, and Langerhans cell depletion from the skin. Studies on human skin fibroblasts by Choi et al have demonstrated that narrowband UVB reduces type I collagen synthesis by down-regulating TGF-beta1 expression at both the mRNA and protein levels and promoting the release of MMP-1. [105] Oiso et al reported flattening of a hypertrophic scar after treating a patient with vitiligo and a Koebner phenomenon with low-dose narrowband UVB (ie, 300 mJ/cm2) once a week for 4 months. [106]


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