What is the role of hydrogel scaffold, in the treatment of keloids and hypertrophic scars?

Updated: May 29, 2020
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Hydrogel scaffold is approved for used in Europe for improvement of wound healing and scarring and is available as an injectable porcine gelatin-dextran hydrogel scaffold. [79] Its approval is for injection of incisional sites immediately prior to closure. It is thought to function as a lattice for fibroblast adherence, leading to more regulated and organized distribution, with improved wound healing outcome.

Hydrogel scaffold has also been studied in the treatment of keloids. Berman et al studied 19 subjects with 26 ear keloids. They were treated with excision followed by injection with 3 mL of the scaffold per 2.5 cm of wound margin, along with wound margin approximation and closure. [80] At 12-month follow-up, the recurrence rate was 19.2%, and each of the recurrences measured less than 15% of the original volume, with 60% of the recurrences measuring less than 5%. As well, the average patient scar satisfaction on a scale of 1-10 was 9.9.

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