Which bleomycin combination therapies are effective in the treatment of keloids and hypertrophic scars?

Updated: Jun 12, 2018
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Manca et al have found that electroporation in combination with bleomycin is an effective treatment for keloids or hypertrophic scars or for those who are nonresponders to other treatments. In their study, 20 patients with keloids or hypertrophic scars had a median reduction of 87% in volume and 94% of the lesions showed volume reduction of more than 50%. Scar pliability and erythema scores were also significantly reduced. Less pruritus was observed in 89% of patients and pain was reduced in 94%. [36]

The combination of bleomycin and intralesional steroids such as triamcinolone has repeatedly shown good results. More recently, Camacho-Martinez et al designed a two-part study. They used 0.375 IU of bleomycin and 4 mg of triamcinolone acetonide to 1 cm2 and it was considered an acceptable procedure for the treatment of keloids. The best results were obtained in keloids larger than 1 cm2 or when divided into 1-cm2 square areas. [37]


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