What is the role of 5-fluorouracil in the treatment of keloids and hypertrophic scars?

Updated: Jun 12, 2018
  • Author: Brian Berman, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Published data show molecular-based evidence of the clinical benefits of adding 5-fluorouracil to a steroid injection for improved scar regression and reduced recurrence of keloids. 5-Fluorouracil–induced G2 cell-cycle arrest and apoptosis may be associated with p53 activation and p21 up-regulation. 5-Fluorouracil significantly affects the treatment when combined with triamcinolone, leading to more significant cell proliferation inhibition, apoptosis, Col-1 suppression, and MMP-2 induction. [9]


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