What is the pathophysiology of papular urticaria?

Updated: Feb 12, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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In a study of the specific pattern of flea antigen recognition by IgG subclass and IgE during the progression of papular urticaria caused by flea bite, variations in the antibody responses of both subclasses to flea antigens were identified. [24] Among these 25 patients, those with 2-5 years of papular urticaria had more IgE bands than patients with shorter or longer durations of symptoms. Thus, the predominant specific antibody isotypes appear to vary according to the time elapsed from the onset of fleabite-induced papular urticaria. [24] The cellular immune response against whole-flea antigen in patients with papular urticaria by flea bites may be the result of an impaired dendritic cell population. [25]  This common insect bite skin hypersensitivity reaction may result from salivary antigen Cte f 2 of the cat flea Ctenocephalides felis. [26]

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