Which medications in the drug class Immunoglobulins are used in the treatment of Common Variable Immunodeficiency?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Immunoglobulins

Ig passively supplies recipients with a broad spectrum of IgG antibodies against bacteria, viruses, and parasites.

Immune globulin intravenous (Gamimune, Gammar-P, Sandoglobulin, Gammagard S/D)

Intravenous immune globulin neutralizes circulating myelin antibodies with anti-idiotypic antibodies. It down-regulates proinflammatory cytokines, including interferon-gamma. It blocks Fc receptors on macrophages and blocks the complement cascade. It suppresses inducer T and B cells and augments suppressor T cells. It also promotes remyelination and may increase CSF IgG levels by 10%.


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