What causes death in patients with common variable immunodeficiency (CVID)?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Death may result. A common cause of death in patients with CVID is lymphoma. Other causes include cor pulmonale secondary to chronic pulmonary infection, liver failure caused by viral or autoimmune hepatitis, malnutrition resulting from gastrointestinal tract disease, and other viral infections. Factors associated with mortality include low levels of IgG, poor T-cell responses to antigens, and a low percentage of peripheral B cells.

Other complications include chronic sinusitis, severe autoimmune thrombocytopenia, and hemolytic anemia.

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