Which histologic findings are characteristic of common variable immunodeficiency (CVID)?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Histologic changes may be observed in the lymph nodes of patients with CVID. Findings may include the following:

  • Reactive follicular hyperplasia

  • Atypical hyperplasia

  • Granulomatous inflammation

Nonsarcoidal, nontuberculoid, asymptomatic cutaneous granulomas seen in CVID show well-demarcated areas of fibrinoid degeneration of collagen that stain homogeneously and are surrounded by histiocytes in a palisading arrangement (suggestive of granuloma annulare). [11]

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