What is the role of lab testing in the workup of common variable immunodeficiency (CVID)?

Updated: Feb 23, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

In patients with CVID, laboratory studies can reveal the following:

  • Serum IgA and IgG levels - Decreased (not absent)

  • Serum IgM levels - Decreased (occasionally)

  • Circulating T and B lymphocytes - Can be assessed by using monoclonal antibodies for immunofluorescence staining

  • T-cell function - In vivo measurement is possible by using an anergy panel to assess localized immunologic skin responses


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