Which antihistamines are preferred for the treatment of chronic urticaria in patients with kidney or liver impairment?

Updated: Jul 31, 2018
  • Author: Marla N Diakow, MD; Chief Editor: William D James, MD  more...
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Answer

For cetirizine, 60% of an administered dose is eliminated via the kidneys; for levocetirizine, the figure is 85%. Most H1 or H2 antihistamines undergo presystemic metabolism in the liver via cytochrome P-450. Accordingly, reduction of low-sedation antihistamine doses is advised in patients with liver or renal failure.


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