What are the histologic findings in chronic urticaria?

Updated: Jul 31, 2018
  • Author: Marla N Diakow, MD; Chief Editor: William D James, MD  more...
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Answer

Characteristic histologic findings include dermal edema, blood vessel dilatation, and a mild perivascular infiltrate predominantly consisting of monocytes and CD4+ lymphocytes; some forms exist in which neutrophils predominate.

Histologic evidence of leukocytoclasia (neutrophilic infiltration with fragmentation of nuclei) is a characteristic feature of urticarial vasculitis. The presence of neutrophils may indicate potential benefit from treatment with dapsone or colchicine.


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