What are the treatment options for cholinergic urticaria?

Updated: Feb 12, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Traditional treatment options for cholinergic urticaria are antihistamines, leukotriene inhibitors, and immunosuppressives. [27, 28] However, cholinergic urticaria in some patients may be refractory.

Sometimes, an attack of cholinergic urticaria can be aborted by rapid cooling. Ultraviolet (UV) light has been beneficial in some patients with the condition, but one must be circumspect about contraindications to UV light.

Rapid desensitization with autologous sweat has been reported in patients resistant to conventional therapy who have sweat hypersensitivity. [29]

In evaluating any response to therapy, one must always consider that cholinergic urticaria can clear spontaneously.

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