What is the role of mast cells in the etiology of cholinergic urticaria?

1. Magerl M, Borzova E, Gimenez-Arnau A, et al. The definition and diagnostic testing of physical and cholinergic urticarias--EAACI/GA2LEN/EDF/UNEV consensus panel recommendations. Allergy. 2009 Dec. 64(12):1715-21. [Medline].

2. Nakamizo S, Egawa G, Miyachi Y, Kabashima K. Cholinergic urticaria: pathogenesis-based categorization and its treatment options. J Eur Acad Dermatol Venereol. 2012 Jan. 26(1):114-6. [Medline].

3. Iwasaki A, Ito T, Kawakami H, Nishiwaki K, Numata T, Saito M, et al. A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. Allergol Int. 2017 Jan 18. [Medline].

4. Soter NA, Wasserman SI. Physical urticaria/angioedema: an experimental model of mast cell activation in humans. J Allergy Clin Immunol. 1980 Nov. 66(5):358-65. [Medline].

5. Montgomery SL. Cholinergic urticaria and exercise-induced anaphylaxis. Curr Sports Med Rep. 2015 Jan. 14(1):61-3. [Medline].

6. Nakazato Y, Tamura N, Ohkuma A, Yoshimaru K, Shimazu K. Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. Neurology. 2004 Oct 26. 63(8):1476-80. [Medline].

7. Takahagi S, Tanaka T, Ishii K, et al. Sweat antigen induces histamine release from basophils of patients with cholinergic urticaria associated with atopic diathesis. Br J Dermatol. 2009 Feb. 160(2):426-8. [Medline].

8. Fukunaga A, Bito T, Tsuru K, et al. Responsiveness to autologous sweat and serum in cholinergic urticaria classifies its clinical subtypes. J Allergy Clin Immunol. 2005 Aug. 116(2):397-402. [Medline].

9. Horikawa T, Fukunaga A, Nishigori C. New concepts of hive formation in cholinergic urticaria. Curr Allergy Asthma Rep. 2009 Jul. 9(4):273-9. [Medline].

10. Hiragun M, Hiragun T, Ishii K, et al. Elevated serum IgE against MGL_1304 in patients with atopic dermatitis and cholinergic urticaria. Allergol Int. 2014 Mar. 63(1):83-93. [Medline].

11. Ramam M, Pahwa P. Is cholinergic urticaria a seasonal disorder in some patients?. Indian J Dermatol Venereol Leprol. 2012 Mar. 78(2):190-1. [Medline].

12. Kobayashi H, Aiba S, Yamagishi T, et al. Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. Dermatology. 2002. 204(3):173-8. [Medline].

13. Itakura E, Urabe K, Yasumoto S, Nakayama J, Furue M. Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. Br J Dermatol. 2000 Nov. 143(5):1064-6. [Medline].

14. Moore-Robinson M, Warin RP. Some clinical aspects of cholinergic urticaria. Br J Dermatol. 1968 Dec. 80(12):794-9. [Medline].

15. Godse K, Farooqui S, Nadkarni N, Patil S. Prevalence of cholinergic urticaria in Indian adults. Indian Dermatol Online J. 2013 Jan. 4(1):62-3. [Medline]. [Full Text].

16. Confino-Cohen R, Goldberg A, Magen E, Mekori YA. Hemodialysis-induced rash: a unique case of cholinergic urticaria. J Allergy Clin Immunol. 1995 Dec. 96(6 Pt 1):1002-4. [Medline].

17. Mellerowicz EJ, Asady A, Maurer M, Altrichter S. Angioedema frequently occurs in cholinergic urticaria. J Allergy Clin Immunol Pract. 2019 Apr. 7 (4):1355-1357.e1. [Medline].

18. Washio K, Fukunaga A, Onodera M, Hatakeyama M, Taguchi K, Ogura K, et al. Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases. J Dermatol Sci. 2017 Feb. 85 (2):135-137. [Medline].

19. Sheraz A, Halpern S. Cholinergic Urticaria Responding to Botulinum Toxin injection for Axillary Hyperhidrosis. Br J Dermatol. 2013 Jan 10. [Medline].

20. Silpa-Archa N, Kulthanan K, Pinkaew S. Physical urticaria: prevalence, type and natural course in a tropical country. J Eur Acad Dermatol Venereol. 2010 Dec 22. [Medline].

21. Vadas P, Sinilaite A, Chaim M. Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. J Allergy Clin Immunol Pract. 2016 Mar-Apr. 4 (2):284-91. [Medline].

22. Torabi B, Ben-Shoshan M. The association of cholinergic and cold-induced urticaria: diagnosis and management. BMJ Case Rep. 2015 Feb 18. 2015:[Medline].

23. Abajian M, Schoepke N, Altrichter S, Zuberbier HC, Maurer M. Physical urticarias and cholinergic urticaria. Immunol Allergy Clin North Am. 2014 Feb. 34(1):73-88. [Medline].

24. Wassef C, Laureano A, Schwartz RA. Aquagenic Urticaria: A Perplexing Physical Phenomenon. Acta Dermatovenerol Croat. 2017 Oct. 25 (3):234-237. [Medline].

25. Mihara S, Hide M. Adrenergic urticaria in a patient with cholinergic urticaria. Br J Dermatol. 2008 Mar. 158(3):629-31. [Medline].

26. Guillén Astete C, Zamorano Serrano M, Luque Alarcón M. Cholinergic synovitis: Description of four cases. Reumatol Clin. 2021 Feb. 17 (2):113-115. [Medline].

27. Otto HF, Calabria CW. A case of severe refractory chronic urticaria: a novel method for evaluation and treatment. Allergy Asthma Proc. 2009 May-Jun. 30(3):333-7. [Medline].

28. Magerl M, Altrichter S, Borzova E, Giménez-Arnau A, Grattan CE, Lawlor F, et al. The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 2016 Jun. 71 (6):780-802. [Medline].

29. Kozaru T, Fukunaga A, Taguchi K, Ogura K, Nagano T, Oka M, et al. Rapid desensitization with autologous sweat in cholinergic urticaria. Allergol Int. 2011 Sep. 60(3):277-81. [Medline].

30. Minowa T, Sumikawa Y, Kan Y, Kamiya T, Uhara H. Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis. Dermatol Ther. 2020 Jul. 33 (4):e13647. [Medline].

31. Ruft J, Asady A, Staubach P, Casale T, Sussmann G, Zuberbier T, et al. Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). Clin Exp Allergy. 2018 Jan 25. [Medline].

32. Mellerowicz E, Weller K, Zuberbier T, Maurer M, Altrichter S. Real-life treatment of patients with cholinergic urticaria in German-speaking countries. J Dtsch Dermatol Ges. 2019 Nov. 17 (11):1141-1147. [Medline].

33. Alsamarai AM, Hasan AA, Alobaidi AH. Evaluation of different combined regimens in the treatment of cholinergic urticaria. World Allergy Organ J. 2012 Aug. 5(8):88-93. [Medline]. [Full Text].

34. Altrichter S, Wosny K, Maurer M. Successful treatment of cholinergic urticaria with methantheliniumbromide. J Dermatol. 2015 Jan 9. [Medline].

35. Ammann P, Surber E, Bertel O. Beta blocker therapy in cholinergic urticaria. Am J Med. 1999 Aug. 107(2):191. [Medline].

36. Tsunemi Y, Ihn H, Saeki H, Tamaki K. Cholinergic urticaria successfully treated with scopolamine butylbromide. Int J Dermatol. 2003 Oct. 42(10):850. [Medline].

37. Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I. Chronic inducible urticaria: classification and prominent features of physical and non-physical types. Acta Dermatovenerol Alp Pannonica Adriat. 2020 Sep. 29 (3):141-148. [Medline].

38. Feinberg JH, Toner CB. Successful treatment of disabling cholinergic urticaria. Mil Med. 2008 Feb. 173(2):217-20. [Medline].

39. Metz M, Bergmann P, Zuberbier T, Maurer M. Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy. Allergy. 2008 Feb. 63(2):247-9. [Medline].

40. Koumaki D, Seaton ED. Successful treatment of refractory cholinergic urticaria with omalizumab. Int J Dermatol. 2018 Jan. 57 (1):114. [Medline].

41. Gastaminza G, Azofra J, Nunez-Cordoba JM, Baeza ML, Echechipía S, Gaig P, et al. Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a Double Dose of Antihistamines: A Randomized Mixed Double-Blind and Open-Label Placebo-Controlled Clinical Trial. J Allergy Clin Immunol Pract. 2019 Jan 15. [Medline].

42. Ihibashi-Kunimi Y, Imafuku S. Cholinergic urticaria with hypohidrosis successfully treated with omalizumab. J Dermatol. 2020 Feb. 47 (2):e47-e48. [Medline].

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Professor of Pediatrics, Professor of Medicine, Rutgers New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, New York Academy of Medicine, Royal College of Physicians of Edinburgh, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Jerri Hoskyn, MD Private Practice, River City Dermatology

Disclosure: Nothing to disclose.

Mark G Lebwohl, MD Chairman, Department of Dermatology, Mount Sinai School of Medicine

Mark G Lebwohl, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Amgen/Pfizer Honoraria Consulting; GlaxoSmithKline Honoraria Consulting; Novartis Honoraria Consulting; Ranbaxy Honoraria Lectures; Pfizer Honoraria Consulting; BioLineRX, Ltd. Honoraria Consulting; Celgene Corporation Consulting; Clinuvel None Investigator; Eli Lilly & Co. None Investigator; Genentech Honoraria Consulting

Christen M Mowad, MD Associate Professor, Department of Dermatology, Geisinger Medical Center

Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.