Which medications in the drug class Antihistamines are used in the treatment of Id Reaction (Autoeczematization)?

Updated: Oct 16, 2020
  • Author: Matthew P Evans, MD; Chief Editor: Dirk M Elston, MD  more...
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These agents relieve pruritus. They may control itching by the blocking effects of endogenously released histamine.

Diphenhydramine (Benadryl, Benylin, Caladryl, Dermapax)

Diphenhydramine is a first-generation antihistamine with anticholinergic effects that binds to H1 receptors in the CNS and the body.

It competitively blocks histamine from binding to H1 receptors. It has significant antimuscarinic activity and penetrates the CNS, which causes a pronounced tendency to induce sedation. Approximately half of those treated with conventional doses experience some degree of somnolence. A small percentage of children paradoxically respond to diphenhydramine with agitation.

It is for symptomatic relief of symptoms caused by the release of histamine in allergic reactions.

Loratadine (Claritin, Alavert)

Loratadine selectively inhibits peripheral histamine H1 receptors. It is tolerated well, with a rate of sedation not significantly different from placebo.

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