What is the pathophysiology of id reaction (autoeczematization)?

Updated: Oct 16, 2020
  • Author: Matthew P Evans, MD; Chief Editor: Dirk M Elston, MD  more...
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While the exact cause of the id reaction is unknown, the following factors are thought to be responsible: (1) abnormal immune recognition of autologous skin antigens, (2) increased stimulation of normal T cells by altered skin constituents, [8, 9] (3) lowering of the irritation threshold, (4) dissemination of infectious antigen with a secondary response, and (5) hematogenous dissemination of cytokines from a primary site. Some cases have been related to medications and intravenous immune globulin. [10] Id reaction has also been noted with BCG therapy. [11]

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