Which medications in the drug class Immunoglobulins are used in the treatment of Drug Eruptions?

Updated: Oct 14, 2020
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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These agents are used to treat TEN.

Intravenous immunoglobulin (Gammagard, Gamimune)

Intravenous immunoglobulin is a blood product prepared from the pooled plasma of healthy donors. The following features are possibly relevant to efficacy: neutralization of circulating myelin antibodies through anti-idiotypic antibodies; down-regulation of proinflammatory cytokines, including IFN-gamma; blockade of Fc receptors on macrophages; suppression of inducer T and B cells and augmentation of T-suppressor cells; blockade of complement cascade; promotion of remyelination; and 10% increase in CSF IgG.

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