Which medications in the drug class First-generation antihistamines are used in the treatment of Drug Eruptions?

Updated: Oct 14, 2020
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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First-generation antihistamines

These agents antagonize H1 receptors and block release of histamine. They provide symptomatic relief of pruritus and help improve eruptions.

Hydroxyzine HCl (Anxanil, Atarax, Atozine, Durrax, Vistaril)

Hydroxyzine antagonizes H1 receptors in the periphery. It may suppress histamine activity in the subcortical CNS. Hydroxyzine is available as 10-, 25-, 50-, or 100-mg tablets.

Diphenhydramine HCl (Benadryl, Benylin, Diphen, AllerMax)

Diphenhydramine is used for symptomatic relief of allergic symptoms caused by the release of histamine in immune reactions.

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