Which histologic findings suggest drug eruption?

Updated: Feb 15, 2019
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

In some cases, biopsy may be helpful in establishing a diagnosis of a drug reaction.

Histopathology of an exanthematous drug eruption may show both superficial and deep perivascular inflammatory cell infiltrates. Eosinophils in the infiltrate suggest such a drug eruption (see the image below).

Superficial perivascular inflammatory infiltrate w Superficial perivascular inflammatory infiltrate with numerous eosinophils characteristic of an exanthematous drug eruption.

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