What are possible etiologies of fibrosing drug eruptions?

Updated: Oct 14, 2020
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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Fibrosing reactions have been associated with a variety of chemical exposures. Nephrogenic systemic fibrosis has been associated with gadolinium contrast agents used for MRI studies. Individuals with renal failure may have a buildup gadolinium in the skin and other organs and may recruit CD34-positive bone marrow–derived fibrocytes into lesional areas. Toxic oil ingestion has been associated with morphea, and Texier disease has been associated with phytomenadione (vitamin-K1) injections.

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