Which features are used to classify nonimmunologically mediated drug eruptions?

Updated: Oct 14, 2020
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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Nonimmunologically mediated reactions may be classified according to the following features: accumulation, adverse effects, direct release of mast cell mediators, idiosyncratic reactions, intolerance, Jarisch-Herxheimer phenomenon, overdosage, or phototoxic dermatitis. (Symptoms of Jarisch-Herxheimer reactions disappear with continued therapy. Drug therapy should be continued until the infection is fully eradicated.)

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