What is the role of antibodies in the pathogenesis of type IV drug eruptions?

Updated: Feb 15, 2019
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Although most drug eruptions are type IV hypersensitivity reactions, only a minority are IgE-dependent. That is, antibodies can be demonstrated in less than 5% of cutaneous drug reactions. Type IV cell-mediated reactions are not dose dependent, they usually begin 7-20 days after the medication is started, they may involve blood or tissue eosinophilia, and they may recur if drugs chemically related to the causative agent are administered.


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