Which clinical features should be the focus of the physical exam for drug eruptions?

Updated: Oct 14, 2020
  • Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD  more...
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Physical examination should address clinical features that may indicate a severe, potentially life-threatening drug reaction, including the following:

  • Mucous membrane erosions

  • Blisters

  • Nikolsky sign

  • Confluent erythema

  • Angioedema and tongue swelling

  • Palpable purpura

  • Skin necrosis

  • Lymphadenopathy

  • High fever, dyspnea, or hypotension

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