Which medications have not been shown to be effective in the treatment of atopic dermatitis (eczema)?

Updated: Mar 13, 2019
  • Author: Brian S Kim, MD, MTR, FAAD; Chief Editor: William D James, MD  more...
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Answer

Unsuccessful therapy with everolimus, a rapamycin-derived macrolide, has been reported in 2 patients with severe AD. Combination therapy with either prednisone or cyclosporine A was not effective. [5] However, reports of the ineffectiveness of everolimus have been questioned. [6]

Results with many other medications, such as thymopentin, gamma interferon, and Chinese herbs, have been disappointing. Many medications are not practical to use, and they can be expensive. Some Chinese herbal preparations contain prescription medications, including prednisone, and have been associated with cardiac and liver problems.

Antibiotics are used for the treatment of clinical infection caused by S aureus or flares of disease. They have no effect on stable disease in the absence of infection. Laboratory evidence of S aureus colonization is not evidence of clinical infection because staphylococcal organisms commonly colonize the skin of patients with AD.


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