What are pharmacologic therapies for enuresis?

Updated: Mar 26, 2020
  • Author: Wm Lane M Robson, MA, MD, FRCP, FRCP(Glasg); Chief Editor: Marc Cendron, MD  more...
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Pharmacologic therapies include the following:

  • Desmopressin acetate (the preferred medication for treating children with enuresis); combination of alarm therapy with desmopressin therapy may yield dryness not achievable with either therapy alone
  • Anticholinergic agents such as oxybutynin chloride and tolterodine (especially in patients with overactive bladder, dysfunctional voiding, or neurogenic bladder); the combination of desmopressin acetate and oxybutynin chloride may be efficacious in children with overactive bladder or dysfunctional voiding who show daytime response to anticholinergic therapy but continue to wet at night; long-acting preparations of oxybutin may be more efficacious for combination therapy with desmopressin
  • Imipramine (because of the unfavorable adverse effect profile and the significant risk of death with overdose, not recommended by the World Health Organization for treatment of enuresis)

See Treatment and Medication for more detail.

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