Which medications in the drug class Vasopressin-Related are used in the treatment of Enuresis?

Updated: Jan 16, 2018
  • Author: Wm Lane M Robson, MA, MD, FRCP, FRCP(Glasg); Chief Editor: Marc Cendron, MD  more...
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Secretion of vasopressin at night reduces urine output. Water is conserved and concentrated by increasing the flow in the kidney through the collecting tubules to the medullary interstitium.

Desmopressin acetate is a synthetic analogue of antidiuretic hormone (ADH). The mechanism of action is presumed to be a reduction in overnight production of urine.

It was later found that some children with bedwetting had lower nocturnal levels of ADH than children who were dry at night.

This finding provided a scientific rationale for desmopressin use; however, not all children with bedwetting have lower levels of ADH at night, overproduce urine at night, or respond to desmopressin. In addition, not all children who respond to desmopressin have lower levels of ADH or overproduce urine at night before being treated with the medication.

Desmopressin, oral (DDAVP)

Desmopressin increases the cellular permeability of collecting ducts, resulting in reabsorption of water by kidneys. It is formulated as a tablet, a disintegrating melt, and as a nasal spray. Because of the risk for severe hyponatremia, the intranasal formulation is no longer indicated for primary enuresis.

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