What is the role of LFA-1 inhibitors in immunosuppression after pediatric transplantation?

Updated: Oct 18, 2019
  • Author: Randy P Prescilla, MD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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LFA-1 inhibitors

Efalizumab (Raptiva) is a humanized IgG1 monoclonal antibody targeting the CD11a chain of LFA-1 (lymphocyte function associated antigen). Efalizumab binds to LFA-1 and prevent the LFA intercellular adhesion molecule interaction, which then results in blocking the T-cell adhesion, trafficking and activation.

Efalizumab, a drug indicated for psoriasis, is being withdrawn from the US market and will no longer be available after June 8, 2009, because of potential risk for progressive multifocal leukoencephalopathy (PML). PML is a rapidly progressive CNS infection caused by JC virus that leads to death or severe disability. Demyelination associated with PML is a result of the JC virus infection. JC virus belongs to the genus Polyomavirus of the Papovaviridae. PML should be considered in any patient with newly onset neurologic manifestations who has taken efalizumab. For more information, see the Food and Drug Administration MedWatch Safety Alert.

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