What is the role of TNF agents in immunosuppression after pediatric transplantation?

Updated: Oct 18, 2019
  • Author: Randy P Prescilla, MD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Anti–tumor necrosis factor (TNF) reagents

Infliximab (Remicade) is an anti-TNF alpha monoclonal antibody that binds with high affinity to TNF-alpha and prevents the cytokine from binding to its receptors. It is approved for treating the symptoms of rheumatoid arthritis, and is used in combination with methotrexate. It is also approved for the treatment of symptoms of moderate-to-severe Crohn disease.

Adalimumab (Humira) is another anti-TNF product. It is approved for use in reducing the signs and symptoms of moderate to severe rheumatoid arthritis, severe polyarticular juvenile rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderate to severe Crohn disease. It is also approved for the treatment of moderate to severe chronic plaque psoriasis.

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