What is the role of FK778 in immunosuppression after pediatric transplantation?

Updated: Oct 18, 2019
  • Author: Randy P Prescilla, MD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Answer

FK778

FK778 is a malononitrilamide (MNA) that has been demonstrated to have both immunosuppressive and anti-proliferative activities. The MNAs inhibit both T-cell and B-cell function by blocking de novo pyrimidine synthesis, through blockade of the pivotal mitochondrial enzyme dihydroorotic acid dehydrogenase (DHODH), and the inhibition of tyrosine kinase activity.

FK778 is a leflunomide derivative. It is derived from an inhibitor of dihydroorotate dehydrogenase, a key enzyme in pyrimidine synthesis. It is undergoing phase 2 trials in kidney transplantation.


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