What is the role of FTY720 in immunosuppression after pediatric transplantation?

Updated: Oct 18, 2019
  • Author: Randy P Prescilla, MD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Answer

FTY720

FTY720 is the first agent in this class. S1P-R agonists reduce recirculation of lymphocytes from the lymphatic system to the blood and peripheral tissues. FTY720 is a synthetic small molecule that is structurally related to myricin, a sphingosine analog. FTY720 reduces the number of circulating T-cells by driving them into lymphoid tissues. Although overall toxicity is low, FTY720 can induce reversible bradycardia with the first few doses. FTY720 is undergoing phase 3 clinical trials.


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