Which medications in the drug class Alkalinizing agents are used in the treatment of Tricyclic Antidepressant Toxicity in Pediatrics?

Updated: Mar 18, 2020
  • Author: Derrick Lung, MD, MPH; Chief Editor: Stephen L Thornton, MD  more...
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Alkalinizing agents

Sodium bicarbonate remains the first-line therapy for cyclic antidepressant-induced cardiotoxicity (eg dysrhythmia, conduction disturbance). Sodium bicarbonate may have beneficial effects in the treatment of cyclic antidepressant-induced seizures, although data have been far less compelling. Prophylactic use is not indicated in a patient who displays no signs of cardiotoxicity. Sodium bicarbonate provides a source of sodium and alkali, both of which are useful in cyclic antidepressant overdose.

Sodium bicarbonate

DOC in limiting cardiovascular morbidity in TCA overdoses.

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