Which tricyclic antidepressants (TCAs) are FDA approved for the treatment of major depressive disorder (MDD) in pediatric patients?

Updated: Mar 18, 2020
  • Author: Derrick Lung, MD, MPH; Chief Editor: Stephen L Thornton, MD  more...
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Only fluoxetine (Prozac) is FDA approved for use in treating major depressive disorder (MDD) in pediatric patients. The selective serotonin reuptake inhibitors (SSRIs) Prozac, sertraline (Zoloft), and fluvoxamine (Luvox) and the cyclic antidepressant clomipramine (Anafranil) are approved for OCD in pediatric patients. None of the drugs is approved for other psychiatric indications in children. [2]

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