Which medications in the drug class Immunomodulators are used in the treatment of Vasculitis and Thrombophlebitis?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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IVIG is used as first-line therapy for Kawasaki disease; it decreases risk of coronary artery aneurysms.

Immune globulin, intravenous (Sandoglobulin, Gamimune, Gamunex, Gammar-P)

Multiple mechanisms. May absorb superantigens or toxins in Kawasaki disease. May saturate available Fc receptors. May block cytokines, cytokine receptors, or both. May absorb complement activation products. May down-regulate immunoglobulin synthesis. Blocks Fc receptors on macrophages. Suppresses inducer T and B cells and augments suppressor T cells. Blocks complement cascade. May increase CSF IgG (10%).

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