Which medications in the drug class Anticoagulant are used in the treatment of Vasculitis and Thrombophlebitis?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

Anticoagulant

These agents provide immediate and long-term treatment of vascular thrombosis.

Heparin

Augments activity of antithrombin III and prevents conversion of fibrinogen to fibrin. Does not actively lyse but is able to inhibit further thrombogenesis. Prevents reaccumulation of clot after spontaneous fibrinolysis.

Provide as continuous heparin infusion to maintain aPTT at 1.5 times the control.

Enoxaparin (Lovenox)

Low molecular weight heparin. Augments activity of antithrombin III and prevents conversion of fibrinogen to fibrin. Does not actively lyse but is able to inhibit further thrombogenesis. Prevents reaccumulation of clot after spontaneous fibrinolysis.

Advantages include intermittent dosing and decreased requirement for monitoring. Heparin anti–factor Xa levels may be obtained if needed to establish adequate dosing.

Warfarin (Coumadin)

Interferes with hepatic synthesis of vitamin K–dependent coagulation factors.


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