What is included in maintenance therapy for ANCA-associated vasculitis?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

Evidence suggests that once remission is achieved with either a cyclophosphamide- or rituximab-based regimen, maintenance therapy is required to prevent relapse. One alternative is to use either methotrexate or azathioprine. A recent study has also suggested the use of biannual rituximab as maintenance therapy. [44] The use of low-dose glucocorticoids (10 mg/d of prednisone) is also recommended. Maintenance therapy should be continued for at least 18-24 months, and early cessation is associated with an increased risk of relapse.


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