How is ANCA-associated vasculitis treated?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

In general, adult patients with ANCA vasculitis are categorized according to different levels of severity to assist treatment decisions, as proposed by the European Vasculitis Study (EUVAS) group. [35]

Table 1. EUVAS disease categorization of ANCA-associated vasculitis (Open Table in a new window)

Category

Definition

Localized

Upper and/or lower respiratory tract disease without any other systemic

involvement or constitutional symptoms

Early

systemic

Any, without organ-threatening or life-threatening disease

Generalized

Renal or other organ-threatening disease, serum creatinine >500

μmol/L (5.6 mg/dL)

Severe

Renal or other vital organ failure, serum creatinine >500 μmol/L (5.6 mg/dL)

Refractory

Progressive disease unresponsive to glucocorticoids and cyclophosphamide


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