What is the role of biopsy in the workup of vasculitis?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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Tissue biopsy may be necessary to confirm a diagnosis of vasculitis in systemic and cutaneous polyarteritis nodosa (PAN), ANCA vasculitides, childhood PACNS, and infrequently in Henoch-Schönlein purpura.

  • Henoch-Schönlein purpura - Skin and/or renal biopsy

  • Polyarteritis nodosa - Skin biopsy

  • ANCA-vasculitides - Sinus, renal, lung, and/or skin biopsy

  • Childhood PACNS - Lesional brain biopsy often needed in small-vessel CNS vasculitis

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