What is thrombophlebitis?

Updated: Dec 10, 2018
  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

Thrombophlebitis refers to inflammation of a vein associated with the formation of a blood clot. This may arise due to an interaction of endothelial injury, stasis of blood, and a hypercoagulable state. Risk factors include intravenous catheter placement, immobilization, malignancy, inherited prothrombotic condition (eg, factor V Leiden, antithrombin III deficiency), antiphospholipid antibody syndrome, and Behçet disease. One study found vascular involvement in 14% of patients with Behçet disease, most commonly manifesting as superficial vein thrombophlebitis or deep vein thrombosis. [9]


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