What are the treatment options for macrophage activation syndrome (MAS) secondary to juvenile idiopathic arthritis (JIA)?

Updated: Jul 25, 2019
  • Author: David D Sherry, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

MAS) is a rare but important complication of systemic-onset JIA in which numbers of all 3 bloodlines become rapidly decreased. Hypofibrinogenemia, thrombocytopenia, and elevated aspartate aminotransferase levels are hallmarks.

MAS often responds to cyclosporin A, and some case reports have detailed a response to anakinra. Treatment of MAS is a medical emergency and should be performed by physicians familiar with this complication.


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