How is macrophage-activating syndrome (MAS) identified in juvenile idiopathic arthritis (JIA)?

Updated: Jul 25, 2019
  • Author: David D Sherry, MD; Chief Editor: Lawrence K Jung, MD  more...
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Answer

In patients with systemic-onset JIA, the following test results are indicative of the development of macrophage-activating syndrome (MAS):

  • Falling ESR

  • Normalization or decrease in white blood cell (WBC) count

  • Low platelets

  • Elevated liver enzymes

  • Increased ferritin

  • Increased triglycerides

  • Low fibrinogen

  • Erratic fevers

  • Hemorrhages (disseminated intravascular coagulation–like pattern)


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